Steve Majerus, Ph.D.
Dr. Steve Majerus received the BS, MS, and PhD degrees in Electrical Engineering from Case Western Reserve University (CWRU) in Cleveland, Ohio, USA. His primary training was in ultra-low-power application-specific integrated circuit (ASIC) design for miniaturized implantable medical devices, and he has developed ASICs for pressure sensing, neural recording, and wideband intravascular ultrasonic imaging. He has additional experience developing ASICs (in Si, SoI, and SiC) for high-temperature and aerospace applications. His doctoral thesis focused on developing and demonstrating the first cystoscopically-implanted, catheter-free bladder pressure monitor.
With the APT Center, Dr. Majerus focuses on translational research by pursuing enabling technologies and demonstrating them in appropriate preclinical or clinical settings. His work is collaborative and generally involves:
· Custom, low-power, miniaturized, wireless circuitry
· Flexible, polymeric substrates and encapsulation methods
· Multiresolution signal processing and classification
· Validation on bench phantoms, preclinical models, and with human patients
Examples of active projects:
1. Closed-loop bladder neuromodulation using catheter-free pressure sensors (both sacral and genital nerve targets in separate studies)
2. Wearable, non-invasive ultrasonic neuromodulation of the tibial nerve to inhibit symptoms of incontinence
3. Wireless, catheter-free sensors for measuring bladder and bowel activity in conscious animals and humans
4. Reduction of high blood pressure using implanted flexible pulsation sensors and autonomic neuromodulation
5. Point-of-care monitoring for hemodialysis vascular access thrombosis risk using flexible microphone arrays and ultrasonic imaging
Photo:Images from Dr. Majerus' work including the Wireless Implantable Bladder Pressure Monitor for Continence and Urinary Health, Micropackage Technology for Implantable Microsystems, and more recent projects in vascular health monitoring. Dr. Majerus' research is multi-disciplinary and focuses on a core competency in low-power, miniaturized electronics combined with microsystem assembly, polymeric packaging, and flexible circuits and sensors. These device examples were each designed to address unmet clinical needs for Veterans with spinal cord injury, end stage renal disease, or peripheral vascular disease.